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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFS
All Species:
25.15
Human Site:
S125
Identified Species:
46.11
UniProt:
P49914
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49914
NP_006432.1
203
23256
S125
D
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Chimpanzee
Pan troglodytes
XP_001154891
203
23207
S125
D
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852666
203
23320
S126
E
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9D110
203
23183
S125
D
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Rat
Rattus norvegicus
NP_001009349
203
23222
S125
D
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516124
97
11478
F43
C
E
I
I
R
D
I
F
Q
R
G
K
T
C
F
Chicken
Gallus gallus
XP_413857
210
23450
A135
S
A
R
E
E
A
L
A
G
G
G
L
D
L
I
Frog
Xenopus laevis
NP_001089249
205
23364
S124
D
C
R
D
D
A
L
S
T
G
G
L
D
L
V
Zebra Danio
Brachydanio rerio
XP_002662791
199
22883
D124
K
H
R
E
E
A
L
D
T
G
G
L
D
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097432
201
22863
T123
E
A
R
E
D
A
M
T
N
G
H
G
I
D
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XWE6
206
23542
E123
W
K
W
Q
S
Y
H
E
T
G
P
L
D
L
I
Sea Urchin
Strong. purpuratus
XP_001183516
161
18411
R107
K
E
G
H
R
L
G
R
G
K
G
Y
Y
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40099
211
24040
P138
I
L
D
V
V
L
V
P
G
V
A
F
D
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
N.A.
86.2
N.A.
83.2
83.2
N.A.
35.4
66.6
55.6
60
N.A.
35.9
N.A.
37.8
42.3
Protein Similarity:
100
100
N.A.
94.5
N.A.
92.6
93
N.A.
43.3
80.9
80.4
80.3
N.A.
59.1
N.A.
55.8
59.1
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
6.6
73.3
73.3
80
N.A.
26.6
N.A.
40
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
80
93.3
80
N.A.
60
N.A.
46.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
70
0
8
0
0
8
0
0
0
0
% A
% Cys:
8
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
39
0
8
8
16
8
0
8
0
0
0
0
77
16
0
% D
% Glu:
16
16
0
62
54
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
8
% F
% Gly:
0
0
8
0
0
0
8
0
24
77
77
8
0
0
0
% G
% His:
0
8
0
8
0
0
8
0
0
0
8
0
0
0
0
% H
% Ile:
8
0
8
8
0
0
8
0
0
0
0
0
8
8
70
% I
% Lys:
16
8
0
0
0
0
0
0
0
8
0
8
0
0
8
% K
% Leu:
0
8
0
0
0
16
62
0
0
0
0
70
0
70
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
70
0
16
0
0
8
0
8
0
0
0
0
0
% R
% Ser:
8
0
0
0
8
0
0
47
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
62
0
0
0
8
0
0
% T
% Val:
0
39
0
8
8
0
8
0
0
8
0
0
0
0
8
% V
% Trp:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _